Systemic lupus erythematosus sle is an autoimmune disease with variable clinical. Both the acr revised criteria and the validated slicc criteria are designed for classification of patients for clinical studies and have not been tested for purposes of diagnosis. The slicc 2012 criteria may allow patients to be classi. The 2012 slicc classification criteria for sle classify a patient as having sle if a the patient satisfies four of the criteria, including at least one clinical criterion and one immunologic. Calculate is a nextgeneration clinical calculator and decision support tool freely available to the medical community. The 2012 slicc criteria classify juvenile patients earlier than the 1997 acr criteria. Discoid rash raised erythematous patches with keratotic scaling, follicular plugging, and atrophic scarring 3. The skin is one of the target organs most variably affected by the disease. Performance of the 2012 systemic lupus international collaborating. If a patient meets at least four criteria, lupus can be diagnosed with 95% specificity and 85% sensitivity.
We suggest combining antimalarial treatment with mepacrine and hydroxychloroquine. The slicc 2012 criteria were more sensitive than the acr 1997 criteria in reallife clinical practice in. Performance of the new slicc classification criteria in childhood systemic lupus erythematosus. Slicc classification criteria for systemic lupus erythematosus. Draft guideline systemic lupus erythematosus sle european. Innovative ways to combine rituximab with benlysta. A multicentre study article pdf available in clinical and experimental rheumatology 323 march. The slicc criteria emphasized that sle is primarily an autoantibody disease, requiring at least one immunologic criterion to be present, and. Slicc criteria for sle slicc classification criteria for sle. The 2012 revised slicc criteria for classification of.
At least four of slicc criteria, including at least one clinical criterion and one immunologic. American college of rheumatology classification criteria for. The systemic lupus international collaborating clinics slicc classification criteria was composed in order to diagnose sle earlier. Pdf performance of the new slicc classification criteria. The european league against rheumatism eular and the american college of rheumatology acr will present the draft of new classification criteria for systemic lupus erythematosus sle during a. Pdf incomplete systemic lupus erythematosus what remains.
Slicc classification criteria may provide useful guidance for the diagnosis. The recent used diagnostic criteria widely used for sle is 2015 acrslicc revised criteria for diagnosis of systemic lupus erythematosus which is based on point systems. The slicc criteria emphasized that sle is primarily an autoantibody disease. Use of slicc criteria in a large, diverse lupus registry enables sle. Neither the acr nor slicc criteria distinguish patients with scle and major.
The slicc 2012 may allow patients to be classified as having sle earlier in the disease course. Joining the dots for patients with systemic lupus erythematosus. Merging malar rash and photosensitivity into one item in slicc12 is the main reason for patients the majority 11, 2229 15, 57 12. Pdf cutaneous manifestations of systemic lupus erythematosus. The systemic lupus international collaborating clinics slicc 2012 criteria were more sensitive than the american college of rheumatology acr 1997 criteria in real.
Systemic lupus erythematosus sle is a multiorgan autoimmune disease of unknown etiology with many clinical manifestations. Mucocutaneous and neuropsychiatric manifestations were added, as were hypocomplementemia and new antiphospholipid antibody tests. Based on sensitivity and specificity slicc12 is best for adult sle. The slicc criteria are more consistent with advancing concepts of sle, and they will exert substantial impact on clinical practice. The slicc criteria for sle classification requires. Updates on lupus 2017 urmc university of rochester. Wetriedto merge the data first published more than twenty. Eular and acr present sle classification criteria at the. Subjects who gain sle classification through slicc criteria exhibit heterogeneous disease, including potential.